Increased reticulocyte count and LDH
Decreased haptoglobin levels (INTRAvascular hemolysis)
Sugar water test Flow cytometry
Negative COOMBs test
Low leukocyte alkaline phosphatase (LAP)
Treatment:
Supportive
Notes:
PNH is the onlyhemolytic anemia caused by an acquired (rather than inherited) intrinsic defect in the cell membrane (deficiency of glycophosphatidylinositol leading to absence of protective proteins on the membrane)