Membranoproliferative nephropathy

• Facts:
  Nephrotic syndrome
  Three types (all three have low serum C3)
  
  Type I
  Subendothelial and mesangial deposits
  Associated with Hepatitis C, cyroglobulinemia, SLE, SBE
  
  Type II (dense deposit disease, DDD)
  Persistent activation of complement pathway
  IgG Abs against C3 convertase (C3 nephritic factor)
  
  Type III
  
• History / PE:
  Proteinuria
  Hematuria
  
• Diagnosis:
  "Tram-track" double-layered basement membrane
  
• Treatment:
  Corticosteroids
  Cytotoxic agents
• Complications:
  Slow progression to renal failure
• Associated With:
  Hepatitis C
• Differential Diagnosis:
  Low complement levels seen in SLE, postinfectious glomerulonephritis , MPGN