Nucleoside analog reverse transcriptase inhibitors NARTI or NRTI
Facts:
First class of antiretroviral drugs developed
Notes:
Zidovudine (AZT, trade name Retrovir)
First HIV antiretroviral drug approved by the FDA
Didanosine (ddI, trade name Videx)
Second FDA-approved antiretroviral drug
Analog of adenosine
Stavudin (d4T, trade names Zerit)
Lamivudine (3TC, trade name Epivir)
Treatment of both HIV and hepatitis B
Abacavir (ABC, trade name Ziagen)
Analog of guanosine
Emtricitabine (FTC, trade name Emtriva [formerly Coviracil] )
Structurally similar to lamivudine
Approved for the treatment of HIV, undergoing clinical trials for hepatitis B
