MC malignancy in males 15-34
95% derive from germ cells, virtually all are malignant
History / PE:
Painless enlargement of testes
Diagnosis:
Testicular U/S
Elevated Beta-hCG (choriocarcinoma and in 10% of seminomas)
Elevated Alpha-fetoprotein (yolk Sac tumors, as well as in hepatocellular carcinoma, hepatoblastoma, and neuroblastoma )
Treatment:
Radical orchiectomy
Seminomas extremely radiosensitive, also respond to chemo
Platinum based chemo for nonseminomatous germ cell tumors
